Who Should Avoid Vitamin D3 and K2 Supplements?

Here at Avacare, we frequently receive enquiries about the suitability of vitamin D3 and K2 and who should not take this supplement. While we can’t provide individual medical advice, we thought it would be helpful to offer some general information to help you make informed decisions about your health. We understand the importance of providing comprehensive information to help you make informed decisions about your health.

Vitamin D3 and K2, the dynamic duo of essential nutrients, offer a compelling range of potential health benefits. When combined with vitamin K2, the benefits of vitamin D are amplified.  From supporting strong bones and teeth to potentially boosting your immune system and promoting cardiovascular well-being, these supplements could be key additions to your wellness journey.


  • Vitamin K2 works synergistically with vitamin D3. Vitamin D3 plays a vital role in calcium absorption, essential for strong bones and teeth. Vitamin K2 then helps direct this calcium to the bones, preventing it from accumulating in unwanted areas like arteries.


  • Both vitamins contribute to a healthy immune system, potentially aiding in the fight against infections and illnesses.


  • Some studies suggest a combined D3 and K2 supplement may contribute to a healthy heart by supporting healthy blood pressure and circulation. Ensuring that calcium is deposited in bones and teeth, rather than accumulating in soft tissues like arteries and joints.


When to Consider Consulting Your Healthcare Professional:

Vitamin D3 and K2 supplements are generally considered safe for most people when taken at appropriate doses. There are certain individuals who should exercise caution or avoid them altogether:

  1. Individuals with Hypercalcemia: Vitamin D can increase calcium absorption in the body. Therefore, people with hypercalcemia (high levels of calcium in the blood) should avoid high doses of vitamin D3, as it may exacerbate their condition.
  2. Those with Kidney Problems: People with kidney disease should be cautious with vitamin D3 and K2 supplements, especially in higher doses. Impaired kidney function can affect the body’s ability to regulate calcium levels properly.
  3. Individuals with Certain Medical Conditions: People with certain medical conditions, such as sarcoidosis, tuberculosis, lymphoma, and other granulomatous disorders, may experience increased calcium levels in the blood when taking vitamin D supplements.
  4. Individuals on Certain Medications: Some medications may interact with vitamin D and K supplements, including corticosteroids, anti-seizure medications, and certain weight-loss drugs. It’s essential to consult with a healthcare professional before starting any new supplement regimen, especially if you are taking medications.
  5. Pregnant and Breastfeeding Women: While vitamin D is crucial for pregnant and breastfeeding women, they should consult with their healthcare provider before taking supplements, especially in higher doses.


Certain individuals may need to consult with their pharmacist or another healthcare professional for personalised advice, particularly those with existing health conditions, medication interactions, or special considerations.

In conclusion, vitamin D3 and K2 supplements offer a myriad of health benefits, including support for bone health, immune function, and cardiovascular health. However, please, consult with your healthcare professional if you are not sure if this supplement is suitable for you.

Avacare’s Vitamin D3 & K2 contains clinically researched doses of both vitamin D and K2 to ensure you are getting the recommended optimum doses. Each dose is delivered in a spray format to ensure optimal absorption.